Science behind motivation
at the University of Washington School of Medicine spent four years looking at
the role of nociceptin peptides (components of cells) in regulating motivation
and as to what happens when we give up.
the brain, a group of cells get very active before a breakpoint. They emit nociceptin,
a complex molecule that suppresses dopamine, a chemical largely associated with
The findings, reported in Cell, offer new insight into the complex world of motivation and reward.
nociceptin peptides are located near an area of the brain known as the Ventral Tegmental
Area. The VTA contains neurons that release dopamine during pleasurable
activities. This study is among the first to describe the effects of this
complex nociceptin modulatory system.In mammals, the neural circuits that
underlie reward seeking are regulated by mechanisms to keep homeostasis - the
tendency to maintain internal stability to compensate for environmental
changes.Deficits within these regulatory processes in humans can manifest as
behavioural dysfunctions, including depression, addiction, and eating disorders.