Science Innovations: Natural Rainbow Colours Produced  |  Technology Inceptions: Muscope, World’s Smallest Microscope  |  Science Innovations: Ultrasensitive Tactile Sensors for Robots  |  Policy Indications: How Materials Science Helps Contain Contain Covid-19 Spread  |  National Edu News: IIT Hyderabad and PharmCADD signed a pact for the co-development of new drugs   |  Teacher Insights: Be Game  |  Health Monitor: Understanding ‘Haemorrhage'  |  National Edu News: Pallikkutam GlobalConnect#3 on 'Innovative Tools for Effective Teaching'  |  Expert Counsel: The Nine Dash Line  |  National Edu News: Astronomers Find One Group of Appearing and Disappearing Stars  |  Teacher Insights: Bird Book for Children to Love Nature  |  International Edu News: New Model to Fight Social Media Deep Fakes  |  Teacher Insights: Universal Lunch Makes Students Healthier  |  Teacher Insights: Physical Activity Boosts Self Regulation  |  Parent Interventions: Anti-Inflammatory Foods Reduce Blood Fats  |  
September 20, 2019 Friday 09:54:25 AM IST

Neural strategy to combat stress

Science Innovations

Researchers in the Department of Brain and Cognitive Sciences at DGIST (Daegu Gyeongbuk Institute of Science and Technology) have discovered that chronic stress causes ‘autophagic’ death of adult hippocampal neural stem cells (NSCs). These findings are expected to open up new strategies for combating stress-associated neural diseases.

Autophagy (self-eating in Greek) is a cellular process to protect cells from unfavourable conditions through digestion and recycling of inner cell materials, which enables cells to remove toxic or old intracellular components and get nutrients and metabolites for survival. However, autophagy can turn into self-destruction process under certain conditions, leading to autophagic cell death.

The death of hippocampal NSCs is prevented when Atg7, one of the major autophagic genes, is deleted. The researchers also found that SGK3 (serum/glucocorticoid regulated kinase3) gene is the trigger for autophagy initiation. Therefore, when SGK3 gene is removed, hippocampal NSCs do not undergo cell death and are spared from stress. 


Comments