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October 20, 2021 Wednesday 12:59:10 PM IST

Immune System Responds Better to Vaccination in Morning Hours

Science Innovations

By deciphering the cell migration mechanisms underlying the immune response of human beings, scientists from the University of Geneva (UNIGE), in Switzerland, and the Ludwigs-Maximilians University (LMU), in Germany, have shown that the activation of the immune system is modulated according to the time of 24 hours. They found that the activation of the immune system oscillates throughout the day, with a peak just before the start of the day. Circadian clock which regulate most of the physiological processes of living beings over a rhythm of about 24 hours, are one of the most fundamental biological mechanisms. To understand the role of circadian rhythms on immune activation, the researchers looked at the migration of dendritic cells from the skin into the lymphatic system, one of the pillars of the adaptive immune response. Located in many peripheral organs, including the skin, dendritic cells migrate through the lymphatic vessels to the lymph nodes, where antigens are presented, in order to trigger an immune response against an incoming pathogen. As a result of the study the scientists suggest that the start of day should possibly be taken into account when administering vaccines or immunotherapies against cancer, in order to increase their effectiveness.


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