Policy Indications: COVID-19: UNICEF continues to ship vital supplies to affected countries   |  International Edu News: WHO Director-General calls on G20 to Fight, Unite, and Ignite against COVID-19  |  Education Information: WHO WhatsApp health alert launches in Arabic, French and Spanish  |  National Edu News: SJVN provides Rs 1 Cr for buying ventilators  |  Science Innovations: DST launches nationwide exercise to map & boost Covid19 solutions   |  National Edu News: Officers and staff of MNRE working from Home through e-office platform  |  National Edu News: Doordarshan to bring back famed Ramayan on Doordarshan National  |  Best Practices: Post Offices provide basic postal and financial services during COVID-19 lockdown  |  Leadership Instincts: Covid-19: Minister directs Kendriya Vidyalaya Sangathan to provide buildings   |  Education Information: National Testing Agency Postpones NEET UG May-2020  |  Leadership Instincts: Fight Corona IDEAthon   |  International Edu News: UK PM Boris Johnson tests positive for coronavirus  |  International Edu News: New mathematical model to track epidemics  |  International Edu News: Low risk of coronavirus spreading through tears  |  Teacher Insights: Language test for people with Fragile X syndrome  |  
March 25, 2020 Wednesday 05:11:34 PM IST

IIT Bombay INSPIRE fellow develops software for radiation therapy

Leadership Instincts

Recipient of the INSPIRE Faculty Award instituted by Department of Science & Technology,  Dr. Achintya Kumar Dutta from IIT Bombay along with his research group is working to develop new methods for quantum chemistry and implement them in efficient and free software to study electron attachment to aqueous DNA which has big implications in radiation therapy-based treatment of cancer.

Indian scientists are at the forefront of the new theory development for quantum chemistry. Dr. Dutta’s research group in IIT Bombay is a collaboration of chemists, computer scientists, and engineers who are united towards a common goal of development of efficient quantum chemistry methods and free software, which can be routinely used by scientists all over the globe to solve their chemistry problems.

“My inspire fellowship has allowed me to establish a state of the art computing facility for developing and testing a new and efficient quantum chemistry software. It also allows me to train quality manpower from all over India who can contribute to the further progress of Indian science,”  tells Dr. Dutta.

The efficiency of these newly developed quantum chemistry methods allows the research group to solve the Schrodinger equation for the attachment of electrons to DNA in the presence of the bulk aqueous environment. The deoxyribonucleic acid or DNA is the carrier of genetic information in the human body, and electron attachment to DNA is one of the crucial steps in radiation damage to human cells. His team has shown that the electron attachment to DNA solvated in bulk water happens through a doorway mechanism, and the presence of the aqueous environment allows this electron attachment to take place at an ultrafast time scale. This newly proposed mechanism of electron attachment to aqueous DNA has big implications in radiation therapy-based treatment of cancer.


This study can help in the development of a new class of radio-sensitizers, which makes tumor cells more sensitive to radiation therapy and thereby protects the normal cells. Computational modeling can greatly reduce the development cost of new radio-sensitizers, both in terms of money and time.

Dr. Dutta wants to use the inspire fellowship to further develop new quantum chemistry methods, benchmark efficient computational protocols to study radiation damage to genetic material and pursue science for the betterment of our society and humankind.


(For more details please contact: Dr. Achintya Kumar Dutta, Email: achintyachemist@gmail.com)



Comments