How Information Theory in Mathematics Can Help Treat Cancer

An effective cure for cancer
need not come from biological sciences alone. Scientists are now examining how
information theory, a mathematical theory most commonly used in computer
science can be used to shed light on cellular communication. Impaired
information transmission in response to changes in environment influences to
the activity of diseased cells, according to researchers at University of
Geneva.
The new methodology is to view
cancer as an information disease and not just cells replicating itself.
Karolina Zielinska, a mathematician and biologist feels that Claude Shannon's
probabilistic theory that led to modern communication systems and computers has
not been applied in cell signalling yet. " Our idea is to use this
powerful tool to examine the decisions made by diseased cells and compare them
to those made by healthy cells."
Applied to cell signalling,
information theory allows studying how cells process the information they
receive from their environment. When a cell receives a stimulus – an
information – from its environment, what concentrations of information can the
cell process without error? Knowing a cell response, can we distinguish between
different stimuli to evaluate which one triggered this particular response?
These questions are essential in the field of cancer. Indeed, cancer cells may
be unable to process information from the environment as well as healthy cells,
and start to proliferate and divide when it is not necessary to do so.
Researchers will now test the
validity of their approach by studying how breast and lung cancer cells process
information from their environment. Indeed, current treatments generally aim to
remove or completely extinguish certain signalling pathways, despite
significant side effects. “The new approach we are proposing is not aimed at
shutting down the signalling pathways, but rather at restoring their proper
activity”, says Vladimir Katanaev. “By applying pure mathematical concepts to
biology, we hope to identify information transmission failures that need to be
fixed to correct them.”
Source Universite De Geneve
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