Career News: 13 Japanese companies to attend JAPAN DAY 2021 @IIT Hyderabad  |  Higher Studies: IELTS Mock Tests: Benefits and Characteristics  |  Teacher Insights: New Features in Moodle 4.0  |  Policy Indications: India-US Launch Climate Action and Finance Mobilisation Dialogue  |  Science Innovations: Stanford University Develops Algorithm to Predict Molecular Structures  |  Technology Inceptions: Oxygen Concentrator, Generation System Developed by Indian Institute of Science  |  Teacher Insights: Early Intervention in Children Good to Prevent Dyslexia  |  Parent Interventions: Cognitive Stimulation Lowers Dementia Risk  |  Parent Interventions: Elderly Cope Better with Pandemic  |  Policy Indications: Use of Copyrighted Works in Online Education  |  Parent Interventions: Maternal Voice Reduces Pain in Preemies  |  Teacher Insights: Eye Sight of Children Affected by Online Learning  |  Expert Counsel: Afghanistan: Top Trouble Spot  |  Best Practices: 'Money Box' Project Gets National Recognition  |  Best Practices: Craft World School Support in Fighting Pandemic  |  
March 30, 2020 Monday 01:35:51 PM IST

CRG standardizes COVID-19 data analysis to aid international research efforts

Leadership Instincts

Researchers from the Centre for Genomic Regulation (CRG) have launched a new database to advance the international research efforts studying COVID-19. The publicly-available, free-to-use resource (https://covid.crg.eu) can be used by researchers from around the world to study how different variations of the virus grow, mutate and make proteins.

To understand how the coronavirus grows, mutates and replicates, scientists have to sequence the RNA of COVID-19. The RNA sequence reveals crucial information about the proteins the virus makes to invade human cells and replicate, which in turn informs governments on the infectiousness and severity of the pandemic.

Traditional sequencing tools can take a long time to provide results. In recent years, sequencing data in real-time has become a reality thanks to the use of nanopore sequencing technologies, revolutionizing genomics research and disease outbreak monitoring. Nanopore sequencing provides scientists and clinicians with immediate access to the DNA and RNA sequence information of any living cell in real-time, enabling a rapid response against the threat of a pandemic.

However, the raw data produced by nanopore sequencing is highly complex. Scientists and clinicians currently lack systematic guidelines for the reproducible analysis of the data, limiting the vast potential of the nascent technology.


To standardize the analysis of publicly available SARS-CoV-2 nanopore sequencing data, researchers at the Centre for Genomic Regulation (CRG) in Barcelona are using MasterOfPores, a computer program developed by the group of Eva Novoa and CRG Bioinformatics Unit. The software was first described last week in Frontiers in Genetics.

MasterOfPores can be executed on any Unix-compatible OS on a computer, cluster or cloud without the need of installing any additional software or dependencies, and is freely available in Github. The publicly-available, free-to-use resource has currently analysed 3TB of SARS-CoV-2 nanopore RNA sequencing data. The CRG researchers will continue to update the resource with new data as soon as it becomes available.


(Content Courtesy: https://www.eurekalert.org/pub_releases/2020-03/cfgr-csc032720.php)



Comments