Teacher Insights: Know about how to choose the best MPPSC coaching institute  |  National Edu News: Swinburne University of Technology & IIT H launch the joint doctoral program  |  Policy Indications: India & Japan collaborations for innovations on Hydrogen based technologies  |  National Edu News: Education Minister addresses at the Annual Convocation of IIM Rohtak  |  Education Information: UPSC postpones tests and Interviews of some examinations  |  National Edu News: Piyush Goyal launches the Startup India Seed Fund Scheme  |  Teacher Insights: Are you Proficient in English?  |  National Edu News: National climate vulnerability assessment sees 8 states as highly vulnerable  |  National Edu News: Education minister e-launches long-lasting hygiene product DuroKea Series  |  National Edu News: Punjab’s new nutrient rich crop varieties can satisfy India's nutritional needs   |  Guest Column: Delicious Dhabas  |  International Edu News: 2D Perovskites for Solar Cells and LEDS  |  International Edu News: AI Model for Predicting Tsunami  |  International Edu News: Wearable Sweat Sensors on a Bandage  |  International Edu News: Smallest High Resolution Microscope  |  
March 30, 2020 Monday 01:35:51 PM IST

CRG standardizes COVID-19 data analysis to aid international research efforts

Leadership Instincts

Researchers from the Centre for Genomic Regulation (CRG) have launched a new database to advance the international research efforts studying COVID-19. The publicly-available, free-to-use resource (https://covid.crg.eu) can be used by researchers from around the world to study how different variations of the virus grow, mutate and make proteins.

To understand how the coronavirus grows, mutates and replicates, scientists have to sequence the RNA of COVID-19. The RNA sequence reveals crucial information about the proteins the virus makes to invade human cells and replicate, which in turn informs governments on the infectiousness and severity of the pandemic.

Traditional sequencing tools can take a long time to provide results. In recent years, sequencing data in real-time has become a reality thanks to the use of nanopore sequencing technologies, revolutionizing genomics research and disease outbreak monitoring. Nanopore sequencing provides scientists and clinicians with immediate access to the DNA and RNA sequence information of any living cell in real-time, enabling a rapid response against the threat of a pandemic.

However, the raw data produced by nanopore sequencing is highly complex. Scientists and clinicians currently lack systematic guidelines for the reproducible analysis of the data, limiting the vast potential of the nascent technology.

To standardize the analysis of publicly available SARS-CoV-2 nanopore sequencing data, researchers at the Centre for Genomic Regulation (CRG) in Barcelona are using MasterOfPores, a computer program developed by the group of Eva Novoa and CRG Bioinformatics Unit. The software was first described last week in Frontiers in Genetics.

MasterOfPores can be executed on any Unix-compatible OS on a computer, cluster or cloud without the need of installing any additional software or dependencies, and is freely available in Github. The publicly-available, free-to-use resource has currently analysed 3TB of SARS-CoV-2 nanopore RNA sequencing data. The CRG researchers will continue to update the resource with new data as soon as it becomes available.

(Content Courtesy: https://www.eurekalert.org/pub_releases/2020-03/cfgr-csc032720.php)