Rajagiri Round Table: Educating India- Listening to Innovative Teachers-76th Rajagiri Round Table  |  Cover Story: A New Era of Instructional Design  |  Best Practices: Continental Hospitals Set up a Super Specialty Clinic in IIT Hyderabad  |  Science Innovations: New cancer treatment developed by MIT  |  Leadership Instincts: Disappearance of Women researchers in Authorship during Pandemic  |  Technology Inceptions: MIT developed a New Successor for Mini Cheetah Robot  |  Science Innovations: IISc team develops novel computational model to predict ‘change blindness’  |  Science Innovations: Immune System Responds Better to Vaccination in Morning Hours  |  Teacher Insights: Training in Childhood Education, New Pedagogy Enabled Innovation in Teaching  |  International Policy: UNESCO Prize for Girls’ and Women’s Education 2021  |  Leadership Instincts: UNESCO Prize for Girls’ and Women’s Education 2021  |  Health Monitor: Intensive therapy better for Cerebral Palsy  |  Parent Interventions: Intensive therapy better for Cerebral Palsy  |  Science Innovations: Intensive therapy better for Cerebral Palsy  |  International Edu News: TutorComp- a new platform for online tutoring in UAE.  |  
August 21, 2019 Wednesday 12:02:08 PM IST

Chemo drug with fewer side effects

Science Innovations

A stealthy new drug-delivery system disguises chemotherapeutics as fat in order to outsmart, penetrate and destroy tumours.Thinking the drugs are tasty fats, tumours invite the drug inside. Once there, the targeted drug activates, immediately suppressing tumour growth. The drug also is lower in toxicity than currentchemotherapy drugs, leading to fewer side effects.

It's like a ‘Trojan horse; It looks like a nice little fatty acid, so the tumour's receptors see it and invite it in. Then the drug starts getting metabolized and kills the tumour cells, according to researchers.

In the study, the researcher sat North-western University used the drug delivery system to carry a common, FDA-approved chemotherapy drug, paclitaxel, into tumours in a small animal model. Disguised as fat, the drug entered and completely eliminated the tumours in three types of cancer - bone, pancreatic and colon.

The researchers found they could deliver 20 times the dose of paclitaxel with their system. But even at such a high quantity, the drug in new system was still 17 times safer.


Comments