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December 20, 2019 Friday 01:38:12 PM IST

Brain Circuit That Causes Compulsive Drinking

The brain circuit that causes compulsive drinking has been identified in a mouse model developed by Cody Siciliano of Vanderbilt University and neuroscientist Kay Tye of the Salk Institute. The activity in the neural circuit can predict which mice will go on a drinking spree despite the negative consequencesweeks in advance.Identifying a brain-based 'bio-marker' for susceptibility to compulsive drinking, the study reveals a potential new target for the development of therapeutics for the Alcohol Use Disorder (AUD), and possibly for the substance use disorders in general.