Anti-Obesity Drugs to Regulate Brain Cells That Control Hunger and Energy
Researchers at Princeton
Neuroscience Institute has identified a group of brain cells responsible for
regulating hunger and energy expenditure in our brain. This could lead to a new
type of weight loss medication that acts on the feelings of hunger and energy
According to Tania Das Banerjee and Alexander Nectow of Princeton, the new drugs will modulate the neurons to decrease hunger and expend more energy. Obesity is a major health issue across the world especially in USA and it causes cardiovascular disease and Type II diabetes.
The researchers were able to find the brain regions in mice that were activated by rise in ambient temperature. This was possible with the use of 3D imaging technique (iDISCO). The neurons in the brain stem called dorsal raphe nucleus was found to regulate hunger and energy expenditure.
The team has started the search for unique receptors in the dual-purpose neurons which govern hunger and energy expenditure to target them using novel anti-obesity drugs.